Rheumatic Fever: ASCHOFF BODY
Aschoff bodies are granulomatous structures consisting of fibrinoid change, lymphocytic infiltration, and characteristically abnormal macrophages surrounding necrotic centres. Some of these macrophages may fuse to form multinucleated giant cells.
In this picture a well-circumscribed lesion is demonstrated in the interstitium of the myocardium. The area of central necrosis is surrounded by a ring of plump histiocytes called Anitschkow or “caterpillar cells”.
Illustration of the Human Heart
The Bielschowsky stain is a technique used in neruopathology that stains certain types of nerve cells with silver nitrate.
Ecthyma gangrenosum is a well recognized cutaneous manifestation of severe, invasive infection by Pseudomonas aeruginosa that is usually seen in immunocompromised and critically ill patients.
Primary neuronal cultures stained for Bornavirus antigens and Tetanus toxin. LSM 710, Caroline Charlier and Daniel Dunia, CPTP Toulouse, France.
WHOI microbiologist Stefan Sievert and colleagues used FISH, or Fluorescence In Situ Hybridization, to localize and identify the microbes living in different parts of the gill chambers of shrimp living near hydrothermal vents.
This image shows two kinds of bacteria attached to a hair-like structure called a seta on the mouth appendages of the shrimp Rimicaris exoculata. The ring-shaped seta (seen here in cross-section) appears blue. Short, thin Gammaproteobacteria appear red, and longer, stouter Epsilonproteobacteria appear green.
Internal Hydrocephalus (by voxel123)
Obstructive internal hydrocephalus due to aqueduct stenosis (triventricular hydrocephalus).
Note the left sided sinusitis.
Volume Rendering of an MRI scan.
Stereo pair to be viewed in crossview technique.
Rendering done with a Carestream workstation.
Hydrocephalus is a condition in which too much cerebrospinal fluid (CSF) accumulates in the brain’s ventricles, the “open” spaces within the brain through which CSF flows. There are several different types of the condition, each of which can occur as a developmental disorder at infancy or due to some other obstruction of CSF flow such as a tumour or infection.
The pressure build up caused by hydrocephalus can result in severe brain damage and symptoms ranging from headaches to seizures, or even cause death.
The condition can be treated with the insertion of a shunt to drain CSF regularly but shunts must be replaced with age and can themselves cause infection.
Notably, one man lived well into middle-age before understanding how severe his case of childhood hydrocephalus was. In fact, the CSF build up was so severe and ventricles so enlarged, his MRI scans indicated he hardly had any brain tissue at all.
Obstructive internal hydrocephalus due to aqueduct stenosis (triventricular hydrocephalus). Note the left sided sinusitis. Volume Rendering of an MRI scan.